On Thanksgiving night, George Noory opened the Secret Door to four different surprise guests. Popping through first was prophecy expert John Hogue who shared insights and predictions. Regarding the economy, we'll probably remain stuck in "neutral gear" for the next six months, he said, as political gridlock continues. This cycle will hopefully be broken by July 2011, with a move toward common ground, he added. Hogue also cautioned that global warming will likely be an issue for the next 200 years, but after that another ice-age cycle could take place.

In the 2nd hour, Steve Alten discussed his new novel, Grim Reaper: End of Days that explores a scenario involving biochemical warfare, in which plague-infected Manhattan neighborhoods serve as an allegory to the nine circles in Dante's Inferno. He also touched on his interest in the Kabbalah, and Mayan prophecy, noting that the last four Mayan cycles ended in cataclysms.

Third through the Secret Door, was John Gray, an expert in the fields of communication and relationships. He spoke about various natural supplements which can aid in optimizing one's health and mental balance, including lithium orotate which when taken in small does, helps to calm the mind, and Tongkat Ali, a natural testosterone booster for men.

In the last hour, author and researcher Lloyd Pye discussed human origins and the Starchild Skull. DNA testing is still in the works to determine if the skull has non-human origins, he reported. He also reviewed the current status of the late Zecharia Sitchin's plan to DNA test the remains of the Sumerian Queen Puabi. Pye said he concurred with Sitchin's interpretation of Sumerian texts that suggest the human race was genetically engineered around 200,000 years ago.