The previous week's guest, author and associate professor at NYU, Charles Seife, returned to discuss a variety of scientific and philosophical topics, including immortality, genetic determinism, quantum computing, teleportation, and multiverses. Seife began with an examination of the beginning of time and the universe, the solution to which he said "may be beyond the reach of science, forever." He did allow that the idea of "an intelligent designer is not contradicted by science."

Seife continued his discussion from the previous week about the theory of information as the basis of all reality and how a complete human brain might be built electronically, creating a virtual immortal being. "Everything creates traces of interactions," such as the simple destruction of a computer hard drive, which leaves traces of itself, Seife said, extrapolating that quantum theories of existence would be correct in the idea that all matter is related to all other matter.

He also delved into questions about our biology and whether death is actually inevitable, according to our DNA. Seife even asked if such traits as sexual orientation could be edited at the genetic level, based on the individual's choice, which brought up issues of free will. The guest also speculated on the existence of an individual's consciousness across multiple universes, suggesting the idea of "quantum immortality," in which a person could exist in multiple universes at different times. The first hour featured news and Open Lines.