In Hour 2, 3, & 4, Dr. Ronald Klatz joins Art to talk about immortality and cloning. He is recognized as a leading authority of anti-aging medicine. He predicted that by 2010 – 2015, we will have reliable methods to "reset our genetic endowment." Klatz also discussed the cloning of human beings and doesn't entirely doubt that the government hasn’t already done it. A caller asks how a cloned human would be kept – alive, animation or frozen? Klatz suggests cloning won’t be the cloning of a full human, but organs and blood instead. Cloning, NDEs, the afterlife, the film Coma, immortality, assisted suicide, health, nutrition, and cancer cures all pop up in this show.

In the first hour, Marshall Barnes comments on a town hall meeting from Ohio State regarding war with Iraq. Barnes was at the conference and said, "CNN almost lost complete control of the whole show."